BPC-157 vs TB-500 — how these two tissue-repair research peptides compare by mechanism, molecular data and research focus. Research Use Only.
BPC-157 vs TB-500 at a glance
| BPC-157 | TB-500 | |
|---|---|---|
| Class / mechanism | Synthetic 15-amino-acid peptide (partial sequence of a gastric-juice protein) | Synthetic actin-binding fragment of Thymosin Beta-4 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV) | — |
| CAS number | 137525-51-0 | 77591-33-4 |
| Research focus | Tissue repair, angiogenesis, cytoprotection, GI-mucosa research | Actin binding, cytoskeletal signaling, cell migration |
| Form | Lyophilized powder | Lyophilized powder |
| Storage | Lyophilized: -20°C long-term; protect from light and moisture | -20°C, protected from light |
What’s the difference?
Both BPC-157 and TB-500 are widely used in tissue-repair research, but they act through different mechanisms. BPC-157 is investigated in angiogenesis, cytoprotection and gastrointestinal-mucosa models, while TB-500 — a fragment of the actin-binding protein Thymosin Beta-4 — is studied for actin binding, cytoskeletal signaling and cell migration. Because the mechanisms are complementary, the two are sometimes examined together, for example in the GLOW research blend.
Which to use in research
In research design, BPC-157 is typically selected where gut, angiogenesis or cytoprotection endpoints are of interest, and TB-500 where actin, cytoskeletal or cell-migration endpoints are the focus. Both are supplied as lyophilised powder and reconstituted the same way.
Handling
All are supplied as lyophilised powder for reconstitution in bacteriostatic or sterile water. See the reconstitution guide and calculator. Each lot ships with a lot-specific Certificate of Analysis.
Learn more
Read the individual overviews: BPC-157 research overview · TB-500 research overview.
Buy for research
Frequently asked questions
Are BPC-157 and TB-500 the same?
No. BPC-157 is a synthetic 15-amino-acid peptide based on a gastric-juice protein sequence, while TB-500 is a synthetic actin-binding fragment of Thymosin Beta-4. They are studied through different mechanisms.
Can BPC-157 and TB-500 be studied together?
Yes. Because their research pathways are complementary they are sometimes examined together, as in the GLOW blend that combines them with GHK-Cu.
Part of our research peptides handbook.